Research on heterocyclic compounds. XXXVII. Synthesis and antiinflammatory activity of methyl-substituted imidazo[1,2-a]pyrazine derivatives

摘要: Summary A series of methyl-substituted imidazo[1,2- a ]pyrazines 8 bearing carboxylic acid group on the imidazole ring were synthesized. The structures new compounds confirmed by 1 H- and 13 C-NMR spectral data; correct assignment carbon resonances was made means HETCOR COLOC experiments. Antiinflammatory, analgesic ulcerogenic activities in vivo evaluated compared with those antiinflammatory imidazopyrazines ( 2 3 ) indomethacin. inhibitory action cyclooxygenase activity vitro. Compounds found to be less potent than indomethacin these assays. SARs are discussed.