Recent advances in development of imidazo[1,2-a]pyrazines: synthesis, reactivity and their biological applications
作者： Richa Goel , Vijay Luxami , Kamaldeep Paul
DOI: 10.1039/C4OB01380H
关键词:
摘要: Imidazo[1,2-a]pyrazine acts as a versatile scaffold in organic synthesis and drug development. This review article is an effort to compile the progress made synthetic methods illustrate its reactivity multifarious biological activity. mainly based on pattern position of substitution, should help scientific community bring about future developments.
rsc.org
sci-hub.se 参考文章(93)
Vivek Polshettiwar, Rajender S. Varma, Greener and expeditious synthesis of bioactive heterocycles using microwave irradiation Pure and Applied Chemistry. ,vol. 80, pp. 777- 790 ,(2008) , 10.1351/PAC200880040777
Thierry O. Fischmann, Alan Hruza, José S. Duca, Lata Ramanathan, Todd Mayhood, William T. Windsor, Hung V. Le, Timothy J. Guzi, Michael P. Dwyer, Kamil Paruch, Ronald J. Doll, Emma Lees, David Parry, Wolfgang Seghezzi, Vincent Madison, Structure-guided discovery of cyclin-dependent kinase inhibitors. Biopolymers. ,vol. 89, pp. 372- 379 ,(2008) , 10.1002/BIP.20868
Magda Kosmopoulou, Chongbo Sun, Amir Faisal, Mizio Matteucci, Jóhannes Reynisson, Nathan Brown, Butrus Atrash, Julian Blagg, Edward McDonald, Spiros Linardopoulos, Richard Bayliss, Vassilios Bavetsias, Nathalie Bouloc, Jonathan M. Large, Structure-based design of imidazo[1,2-a]pyrazine derivatives as selective inhibitors of Aurora-A kinase in cells. Bioorganic & Medicinal Chemistry Letters. ,vol. 20, pp. 5988- 5993 ,(2010) , 10.1016/J.BMCL.2010.08.091
Sarah M. Ireland, Heather Tye, Mark Whittaker, Microwave-assisted multi-component synthesis of fused 3-aminoimidazoles Tetrahedron Letters. ,vol. 44, pp. 4369- 4371 ,(2003) , 10.1016/S0040-4039(03)00941-9
Vikas Tyagi, Shahnawaz Khan, Vikas Bajpai, Harsh M. Gauniyal, Brijesh Kumar, Prem M. S. Chauhan, Skeletal Diverse Synthesis of N-Fused Polycyclic Heterocycles via the Sequence of Ugi-Type MCR and CuI-Catalyzed Coupling/Tandem Pictet–Spengler Reaction The Journal of Organic Chemistry. ,vol. 77, pp. 1414- 1421 ,(2012) , 10.1021/JO202255V
Angela D. Kerekes, Sara J. Esposite, Ronald J. Doll, Jayaram R. Tagat, Tao Yu, Yushi Xiao, Yonglian Zhang, Dan B. Prelusky, Seema Tevar, Kimberly Gray, Gaby A. Terracina, Suining Lee, Jennifer Jones, Ming Liu, Andrea D. Basso, Elizabeth B. Smith, Aurora Kinase Inhibitors Based on the Imidazo[1,2-a]pyrazine Core: Fluorine and Deuterium Incorporation Improve Oral Absorption and Exposure Journal of Medicinal Chemistry. ,vol. 54, pp. 201- 210 ,(2011) , 10.1021/JM1010995
Isao Hyodo, Mamoru Tobisu, Naoto Chatani, Catalytic Arylation of a CH Bond in Pyridine and Related Six-Membered N-Heteroarenes Using Organozinc Reagents Chemistry - An Asian Journal. ,vol. 7, pp. 1357- 1365 ,(2012) , 10.1002/ASIA.201100971
Jason G. Kettle, Simon Brown, Claire Crafter, Barry R. Davies, Phillippa Dudley, Gary Fairley, Paul Faulder, Shaun Fillery, Hannah Greenwood, Janet Hawkins, Michael James, Keith Johnson, Clare D. Lane, Martin Pass, Jennifer H. Pink, Helen Plant, Sabina C. Cosulich, Diverse heterocyclic scaffolds as allosteric inhibitors of AKT. Journal of Medicinal Chemistry. ,vol. 55, pp. 1261- 1273 ,(2012) , 10.1021/JM201394E
Yadigar Gülseven Sıdır, İsa Sıdır, Quantitative structure activity relationships of cytotoxicity effect on various cancer cells of some imidazo[1,2-?]pyrazine derivatives Bitlis Eren University Journal of Science and Technology. ,vol. 3, pp. 9- 14 ,(2015) , 10.17678/BEUSCITECH.47133
Seref Demirayak, Ismail Kayagil, Synthesis of some 6,8-diarylimidazo[1,2-a]pyrazine derivatives by using either reflux or microwave irradiation method and investigation of their anticancer activities Journal of Heterocyclic Chemistry. ,vol. 42, pp. 319- 325 ,(2005) , 10.1002/JHET.5570420224