Thiophenes and furans derivatives: a new class of potential pharmacological agents
作者： Flavia C Meotti , Dagoberto O Silva , Adair R.S dos Santos , Gilson Zeni , Joao Batista T Rocha
DOI: 10.1016/J.ETAP.2003.08.008
关键词:
摘要: A new class of potential pharmacological thiophenes and furans compounds has been prepared. The obtained derivatives were screened for anti-inflammatory, antinociceptive antioxidant activity in rats. In vitro hepatic ALA-D was also evaluated. Thiophene 2 exhibited higher anti-inflammatory effect than 1 3. However, compound demonstrated lower IC50 lipid peroxidation 3 liver brain. Furan 4 � /6 presented similar antiinflammatory activity. acetylenic 5 inhibited scarcely at low concentration as 10 mM. Conversely, furan 6 the most effective against liver. Furans peroxidation, brain, only high concentrations. contrast, protected (90%) devoid but efficient reducing acetic acid-induced constriction. it analogue All displayed however is not related to potential.
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