Antioxidant effect of a novel class of telluroacetilene compounds: studies in vitro and in vivo.
作者： Ana Cristina G. Souza , Cristiane Luchese , Jose S. Santos Neto , Cristina W. Nogueira
DOI: 10.1016/J.LFS.2008.12.021
关键词: Biochemistry 、 Oxidative stress 、 DPPH 、 In vivo 、 Glutathione peroxidase 、 Glutathione 、 Antioxidant 、 Glutathione reductase 、 Chemistry 、 Pharmacology 、 Lipid peroxidation
摘要: Abstract Aims The effect of telluroacetylenes a–d on pharmacological assays was investigated in vitro. A second objective this study to investigate the antioxidant action compound b against oxidative damage induced by sodium nitroprusside (SNP) mouse brain. Main methods In vitro experiments, lipid peroxidation (LP) and protein carbonyl (PC) levels δ-aminolevulinate dehydratase (δ-ALA-D) activity were carried out rat brain homogenate. thiol peroxidase-like DPPH radical scavenging investigated. vivo mice received SNP (0.335 µmol per site) intra cerebroventricular (i.c.v.) thirty minutes after oral administration telluroacetylene (10 mg/kg). After 1 h, animals euthanized. LP δ-ALA-D, catalase (CAT), glutathione peroxidase (GPx), reductase (GR), S-transferase (GST) activities Key findings Telluroacetylenes a–d, at low μM range, reduced PC showed radicals. δ-ALA-D inhibited telloruacetylenes high Brains treated with an increase reduction GR GST activities. Telluroacetylene protected stress caused rats. Significance results support brain, suggesting compound.
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