Targeting survivin in cancer: novel drug development approaches.

摘要: Survivin is a well-established target in experimental cancer therapy. The molecule over-expressed most human tumors, but hardly detectable normal tissues. Multiple functions different subcellular compartments have been assigned. It participates the control of cell division, apoptosis, cellular stress response, and also regulation migration metastasis. expression has recognized as biomarker: high indicates an unfavorable prognosis resistance to chemotherapeutic agents radiation treatment. unconventional drug several indirect approaches exploited affect its function phenotype survivin-expressing cells. Interference with survivin gene, utilization messenger RNA, intracellular localization, interaction binding partners, stability protein, induction survivin-specific immune responses taken into consideration. A direct strategy inhibit based on identification specifically interacting peptide. This peptide can recognize intracellularly cause degradation ligand–survivin complex. Technology being developed that might allow derivation small molecular-weight, drug-like compounds are functionally equivalent ligand.