RNA Interference-Mediated Validation of Survivin and Apollon/BRUCE as New Therapeutic Targets for Cancer Therapy

摘要: The ability to evade apoptosis is one of the defining hallmarks cancer. It enables survival cancer cells under abnormal growth stimulation and mediates their increased resistance treatment with cytotoxic drugs radiation. Therefore, antiapoptotic proteins that counteract signaling represent promising new therapeutic targets impair cell enhance response. As soon as RNA interference (RNAi) was demonstrated in mammalian cells, it rapidly became an essential tool for gene knockdown preclinical models, making possible define role specific genes onset progression explore potential targets. present review summarizes findings from studies relying on use RNAi-based approaches functionally validate two members inhibitors protein family, survivin Apollon/BRUCE, Results collected thus far indicate targeting network efficiently inhibits tumor increases spontaneous treatment-induced cells. Based these findings, applicability survivin-directed strategies clinical human tumors currently investigation. regards Apollon/ BRUCE, although very preliminary, results RNAi-mediated point possibility significantly proliferation through induction apoptosis.