Functional plurihormonal adrenal oncocytoma: case report and literature review.

摘要: Oncocytomas or oncocytic neoplasms are composed of tumor cells that show abundant granular eosinophilic cytoplasm by microscopy, and which may adopt an alveolar, tubular, solid pattern 1. Ultrastructurally, is caused massive accumulation mitochondria 2. The organs most commonly involved the kidney, salivary glands, thyroid gland. However, cases have been reported in parathyroid pituitary gland, larynx, liver, breast, ovary, stomach, small intestine, thymus, prostate, lung 1, 3, 4, 5, 6, 7. When located retroperitoneum, be either renal adrenal origin. Limited retroperitoneal heterotopic oncocytomas 8, 9, 10. Oncocytic arising from gland rare: 1.8% masses, predominantly affecting adult population 11. Most these tumors involve adrenocortical region, while pheochromocytomas extremely rare 12. Since first description 1986, confirmed electron microscopy 13, approximately 147 literature 14, them described as incidentalomas. They traditionally considered benign nonfunctional tumors, although recent data suggest 20% some elements malignancy 10–20% funcional 15. According to their biologic behavior, classified malignant, borderline (or uncertain malignant potential), benign, based on criteria proposed 2004 Bisceglia et al. 15. This classification includes major criteria: venous invasion, presence atypical mitoses, a high mitotic rate (more than five mitoses per 50 high‐power fields) minor necrosis, size >10 centimeters weight >200 g, capsular sinusoidal invasion. The at least one criterion indicates malignancy, potential (borderline). absence indicative oncocytoma. As oncocytoma very entity, aim this article was report case plurihormonal provide review clinical, biochemical, pathological features literature.