Mechanisms of immune lysis. II. CTL-induced nuclear disintegration of the target begins within minutes of cell contact.
作者： C B Dobos , J H Russell
DOI:
关键词: Virology 、 Cell contact 、 Immune system 、 Intracellular 、 Cell biology 、 Lytic cycle 、 Primary event 、 CTL* 、 Lysis 、 Biology 、 Cell nucleus
摘要: Within minutes of CTL-target interaction, the intracellular disintegration target cell nucleus begins. This nuclear event satisfies ionic and temperature requirements that have been described by others as important in CTL-mediated lysis. Such does not occur Ab+C-lysed targets. Thus appears to signal a primary lysis distinguishes CTL lytic mechanism from Ab+C.
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