Apoptosis in Focal Cerebral Ischemia

摘要: An ischemic insult to the brain evokes cell damage which may progress death. We invariably associate death with necrosis. Necrosis exhibits well defined morphological characteristics, and biochemical biophysical processes associated necrosis have been identified. However, another form of exists, apoptosis. Apoptosis plays an important role in early development tissues. Cells undergoing apoptosis exhibit very different characteristics temporal profiles change from cells has identified internucleosomal fragmentation DNA. More importantly, a process programmed death, genetic program is activated results cell. In this presentation, we will review our data on morphological, molecular evidence rodent (rat, mouse) after middle cerebral artery occlusion. Emphasis be placed describing profile anatomical distribution as functions duration MCA occlusion reperfusion The possible contribution selective genes promoting and/or inhibiting also discussed.