Neuroprotective effect of nitroglycerin in a rodent model of ischemic stroke: evaluation of Bcl-2 expression.
作者： Rosaria Greco , Diana Amantea , Fabio Blandini , Giuseppe Nappi , Giacinto Bagetta
DOI: 10.1016/S0074-7742(07)82024-1
关键词: Ischemia 、 Nitric oxide 、 Pharmacology 、 NMDA receptor 、 Anesthesia 、 Penumbra 、 Caspase 、 Apoptosis 、 Neuroprotection 、 Medicine 、 Brain damage
摘要: … Bcl‐2 is a protooncogene that plays a major antiapoptotic … on the potential effects on Bcl‐2 expression. Male Wistar rats … reperfusion, while cortical Bcl‐2 expression was evaluated at …
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sci-hub.se 参考文章(58)
Michael Chopp, Y. Li, Apoptosis in Focal Cerebral Ischemia Acta Neurochirurgica. ,vol. 66, pp. 21- 26 ,(1996) , 10.1007/978-3-7091-9465-2_4
Stuart A Lipton, Posina V Rayudu, Yun-Beom Choi, Nikolaus J Sucher, HS-Vincent Chen, None, Redox modulation of the NMDA receptor by NO-related species Progress in Brain Research. ,vol. 118, pp. 73- 82 ,(1998) , 10.1016/S0079-6123(08)63201-X
T Liu, G Z Feuerstein, F C Barone, Cytokines, inflammation, and brain injury: role of tumor necrosis factor-alpha. Cerebrovascular and brain metabolism reviews. ,vol. 6, pp. 341- 360 ,(1994)
Steven H. Graham, Jun Chen, R. Anne Stetler, R. Li Zhu, Kun Lin Jin, Roger P. Simon, Expression of the proto-oncogene bcl-2 is increased in the rat brain following kainate-induced seizures Restorative Neurology and Neuroscience. ,vol. 9, pp. 243- 250 ,(1996) , 10.3233/RNN-1996-9407
Hui Li, Frederick Colbourne, Ping Sun, Zonghang Zhao, Alastair M. Buchan, Caspase Inhibitors Reduce Neuronal Injury After Focal but Not Global Cerebral Ischemia in Rats Stroke. ,vol. 31, pp. 176- 182 ,(2000) , 10.1161/01.STR.31.1.176
S Krajewski, JK Mai, M Krajewska, M Sikorska, MJ Mossakowski, JC Reed, Upregulation of bax protein levels in neurons following cerebral ischemia The Journal of Neuroscience. ,vol. 15, pp. 6364- 6376 ,(1995) , 10.1523/JNEUROSCI.15-10-06364.1995
MS Lawrence, DY Ho, GH Sun, GK Steinberg, RM Sapolsky, OVEREXPRESSION OF BCL-2 WITH HERPES SIMPLEX VIRUS VECTORS PROTECTS CNS NEURONS AGAINST NEUROLOGICAL INSULTS IN VITRO AND IN VIVO The Journal of Neuroscience. ,vol. 16, pp. 486- 496 ,(1996) , 10.1523/JNEUROSCI.16-02-00486.1996
I. Ferrer, E. Pozas, E. López, J. Ballabriga, Bcl-2, Bax and Bcl-x expression following hypoxia-ischemia in the infant rat brain. Acta Neuropathologica. ,vol. 94, pp. 583- 589 ,(1997) , 10.1007/S004010050753
C. Tassorelli, F. Blandini, R. Greco, G. Nappi, Nitroglycerin enhances cGMP expression in specific neuronal and cerebrovascular structures of the rat brain. Journal of Chemical Neuroanatomy. ,vol. 27, pp. 23- 32 ,(2004) , 10.1016/J.JCHEMNEU.2003.08.006
Jun Chen, Raymond L. Zhu, Masaki Nakayama, Kenji Kawaguchi, Kunlin Jin, R. Anne Stetler, Roger P. Simon, Steven H. Graham, Expression of the Apoptosis-Effector Gene, Bax, Is Up-Regulated in Vulnerable Hippocampal CA1 Neurons Following Global Ischemia Journal of Neurochemistry. ,vol. 67, pp. 64- 71 ,(2002) , 10.1046/J.1471-4159.1996.67010064.X