Modular co-option of cardiopharyngeal genes during non-embryonic myogenesis

作者: Maria Mandela Prünster , Lorenzo Ricci , Federico Brown , Stefano Tiozzo

DOI: 10.1101/443747

关键词: BiologyEmbryogenesisRegeneration (biology)Cell biologyEmbryoEmbryonic stem cellBotryllus schlosseriTBX1MyogenesisHeart development

摘要: In chordates cardiac and body muscles arise from different embryonic origins. Myogenesis can in addition be triggered adult organisms, during asexual development or regeneration. the nonvertebrate ascidians, originate precursors regulated by a conserved set of genes that orchestrate cell behavior dynamics development. colonial besides embryogenesis metamorphosis, an propagate asexually via blastogenesis, skipping embryo larval stages, form anew body, including complete musculature. To investigate cellular origin mechanisms trigger non-embryonic myogenesis, we followed expression ascidian myogenic Botryllus schlosseri reconstructed muscle precursors. Based on Tbx1/10, Ebf, Mrf, Myh3 for wall FoxF, Nk4, Myh2 heart show factors regulating myogenesis are only partially co-opted propose contributing to have Regardless developmental pathway, shares similar molecular anatomical setup as but implements co-option loss modules.

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