Genome composition analysis of reassortant influenza viruses used in seasonal and pandemic live attenuated influenza vaccine
作者： I. V. Kiseleva , J. T. M. Voeten , L. C. P. Teley , N. V. Larionova , I. A. Dubrovina
DOI: 10.3103/S0891416811040045
关键词: Biology 、 Neuraminidase 、 Virus 、 Attenuated vaccine 、 H5N1 genetic structure 、 Virology 、 Microbiology 、 Antigenic drift 、 Pandemic 、 Live attenuated influenza vaccine 、 Reassortant Viruses 、 Genetics 、 Molecular biology 、 Infectious Diseases
摘要: The cold-adapted, temperature sensitive and attenuated influenza master donor viruses A/Leningrad/134/17/57 (H2N2) B/USSR/60/69 were used to generate vaccine be included in live vaccine. These typically are 6: 2 reassortant containing the gene segments of surface antigens haemagglutinin neuraminidase current wild type A B with encoding internal viral proteins, conferring phenotype, being inherited from viruses. selected co-infections between virus that theoretically may yield as many 256 combinations thus genetically different As time isolate is limited because only allowed viruses, sboth selection creening needs both rapid unambiguous. screening by RT-PCRs using specific primer sets described select seasonal pandemic vaccine, unambigously.
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