Redox subpopulations and the risk of cancer progression: a new method for characterizing redox heterogeneity

摘要: It has been shown that a malignant tumor is akin to complex organ comprising of various cell populations including cells are genetically, metabolically and functionally different. Our redox imaging data have demonstrated intra-tumor heterogeneity in all mouse xenografts derived from human melanomas, breast, prostate, colon cancers. Based on the signals NADH oxidized flavoproteins (Fp, including flavin adenine dinucleotide (FAD)) their ratio, i.e., which an indicator mitochondrial metabolic status, we have discovered several distinct subpopulations breast tumors potentially recapitulating functional/metabolic within tumor. Furthermore, of breast tumors with higher metastatic potential tend subpopulation whose ratio is significantly different lower usually bi-modal distribution ratio. The cancer samples can also be very complex multiple as determined by fitting histograms multi- Gaussian functions. In this report, present new method for identifying within individual tissues, may used differentiate between breast normal tissue among risks progression.