Fructose supplementation worsens the deleterious effects of short‐term high‐fat feeding on hepatic steatosis and lipid metabolism in adult rats

摘要: New Findings What is the central question of this study? In humans, ‘Western-style’ diet characterized by high levels both saturated fats and fructose. Lipid oversupply to liver typical high-fat diets could be exacerbated coexistence fat fructose in diet, thus accelerating development metabolic deregulation. What main finding its importance? Short-term consumption a Western rich fructose, more conducive steatosis deleterious glucose homeostasis than diet. This result points harmful effect adding usual Western, diet. The purpose present study was examine short-term or high-fat–high-fructose feeding on hepatic lipid metabolism mitochondrial function adult sedentary rats. Adult male rats were fed for 2 weeks. Body composition, steatosis, plasma profile insulin sensitivity, together with whole-body de novo lipogenesis, assessed. Hepatic mass, functionality, oxidative stress antioxidant defense also measured. Rats exhibited significantly higher triglycerides, non-esterified fatty acids, indexes resistance compared low-fat triglycerides ceramide, as well degree necrosis, higher, while p-Akt lower, A significant increase non-protein respiratory quotient acid synthase stearoyl CoA desaturase activity found those Significantly lower capacity but mass increased only In conclusion,