Fructose and liver function – is this behind nonalcoholic liver disease?

摘要: Purpose of review The purpose was to summarize recent advances in the understanding nonalcoholic fatty liver disease (NAFLD) pathophysiology and role fructose NAFLD. Recent findings Epidemiological studies continue point a strong association between high intake NAFLD its severity. New reveal importance upregulated de novo lipogenesis as key feature along with increased visceral adiposity alteration gut microbiome. Studies show how this nutrient may uniquely exacerbate phenotype timing exposure be important early (in utero) being particularly harmful. Summary Fructose is potentially modifiable environmental that appears through multiple mechanisms. Although larger, longer clinical are still needed, it limitation sources diet beneficial