Nitrogen containing heteroaromatics with ortho-substituted P1's as factor Xa inhibitors
作者： Karen A. Rossi , Donald J. P. Pinto , Lori L. Bostrom , Robert A. Galemmo
DOI:
关键词: Nitrogen 、 Salt (chemistry) 、 Factor Xa Inhibitor 、 Organic chemistry 、 Chemistry 、 Prodrug
摘要: The present application describes nitrogen containing heteroaromatics with ortho-substituted P1's and derivatives thereof of formula I: or pharmaceutically acceptable salt prodrug forms thereof, wherein J is N NH D substituted ortho to G on E may be CH2NH2, which are useful as inhibitors factor Xa.
lens.org参考文章(13)
Masaaki Matsuo, Kiyoshi Tsuji, Takashi Ogino, Nobukiyo Konishi, Pyrazole derivatives with antiinflammatory, analgesic and antithrombolic activity ,(1993)
Toshiki Fukuchi, Yoji Takahashi, Shuko Okui, Itaru Okada, Pyrazole derivative, insecticidal or miticidal composition containing the same as the effective ingredient ,(1988)
James Russell Pruitt, Karen Anita Rossi, Joseph Cacciola, Donald Joseph Phillip Pinto, Qi Han, Michael James Orwat, Mimi Lifen Quan, John Matthew Fevig, NITROGEN CONTAINING HETEROAROMATICS AS FACTOR Xa INHIBITORS ,(1997)
Masaaki Matsuo, Kiyoshi Tsuji, Nobukiyo Konishi, Katsuya Nakamura, Pyrazole derivatives, processes for preparation thereof and pharmaceutical composition comprising the same ,(1990)
Frank Himmelsbach, Elke Seewaldt-Becker, Johannes Weisenberger, Guenter Linz, Volkhard Austel, Thomas Mueller, Helmut Pieper, 5-membered heterocyclic compounds, processes for preparing them and pharmaceutical compositions containing these compounds ,(1992)
James Russell Pruitt, Patrick Yuk-Sun Lam, Qi Han, Mimi Lifen Quan, Celia Dominguez, Robert Anthony Galemmo, Donald Joseph Philip Pinto, John Matthew Fevig, Inhibitors of factor Xa with a neutral P1 specificity group ,(1998)
Jeffrey R. Jackson, James D. Winkler, Use of csaid?tm compounds as inhibitors of angiogenesis ,(1997)
Alfred P. Spada, Yong Mi Choi-Sledeski, Daniel L. Cheney, Michael R. Becker, William R. Ewing, Henry W. Pauls, Jonathan Stephen Mason, Substituted (sulfinic acid, sulfonic acid, sulfonylamino or sulfinylamino) n- (aminoiminomethyl)phenylalkyl -azaheterocyclylamide compounds ,(1996)
William Frank Degrado, Chu-Biao Xue, Compounds containing basic and acidic termini useful as fibrinogen receptor antagonists ,(1994)
Bruce E. Tomczuk, Carl R. Illig, Richard M. Soll, Tianbao Lu, Amidino and guanidino heterocyclic protease inhibitors ,(1997)