Application of IL-36R antagonist in preparing pain-relieving drug

作者: Zhou Junmei , Li Lingling , Li Qian

DOI:

关键词: Thermal HyperalgesiaDrugPharmacologyIntrathecalNeuralgiaMedicineInflammatory painAntagonistMechanical Allodynia

摘要: The invention relates to an application of IL-36R antagonist in preparing a pain-relieving drug. finds that intrathecally taken is capable relieving the painful behavior responses, including mechanical allodynia and thermal hyperalgesia, rat inflammatory pain neuralgia, quickly becoming effective greatly long lasting time, so can be used as composition drug, further prepared into drug for clinically treating pain, especially neuralgia.

参考文章(10)
Abdijapar Shamshiev, Thorsten Alexander Schafer, Simone Schmitt, Stefanie Grabulovski, Titus Kretzschmar, Binding members to il-1 beta ,(2013)
D.B. Bas, S. Abdelmoaty, K. Sandor, S. Codeluppi, B. Fitzsimmons, J. Steinauer, X.Y. Hua, T.L. Yaksh, C.I. Svensson, Spinal release of tumour necrosis factor activates c-Jun N-terminal kinase and mediates inflammation-induced hypersensitivity European Journal of Pain. ,vol. 19, pp. 260- 270 ,(2015) , 10.1002/EJP.544
Cem Gabay, Jennifer E. Towne, Regulation and function of interleukin-36 cytokines in homeostasis and pathological conditions. Journal of Leukocyte Biology. ,vol. 97, pp. 645- 652 ,(2015) , 10.1189/JLB.3RI1014-495R
Yan-jing Yang, Liang Hu, Ye-peng Xia, Chun-yi Jiang, Chen Miao, Chun-qing Yang, Miao Yuan, Lin Wang, Resveratrol suppresses glial activation and alleviates trigeminal neuralgia via activation of AMPK Journal of Neuroinflammation. ,vol. 13, pp. 84- 84 ,(2016) , 10.1186/S12974-016-0550-6
Ya-Qun Zhou, Zheng Liu, Zhi-Heng Liu, Shu-Ping Chen, Man Li, Allahverdi Shahveranov, Da-Wei Ye, Yu-Ke Tian, Interleukin-6: an emerging regulator of pathological pain Journal of Neuroinflammation. ,vol. 13, pp. 141- 141 ,(2016) , 10.1186/S12974-016-0607-6
Martin Nicklin, Jenny Barton, The il-1l1 gene and polypeptide products ,(2000)
Reinaldo Pamplona Gras, Manuel Portero Otin, Mariona Jove Font, Adolfo Jose Lopez De Munain Arregi, Aurora Pujol Onofre, Stephane Fourcade, Methods and compositions for the diagnosis and for the treatment of adrenoleukodystrophy ,(2015)
Salfeld Jochen G, Anwar Murtaza, Edward Tracey Daniel, Spiegler Clive E, Steven Fischkoff, Philip Yan, Taylor Lori K, Hoffman Rebecca S, Subhashis Banerjee, Keith Chartash Elliot, Barchuk William T, Medicament for treating TNF alpha related disorder ,(2012)