Signaling Mechanisms of Vav3, a Guanine Nucleotide Exchange Factor and Androgen Receptor Coactivator, in Physiology and Prostate Cancer Progression

摘要: The Rho GTPase guanine nucleotide exchange factor (GEF) Vav3 is the third member of Vav family GEFS and activated by tyrosine phosphorylation. Through stimulation activity, promotes cell migration, invasion, other cellular processes. Work from our laboratory first established that upregulated in models castration-resistant prostate cancer progression enhances androgen receptor as well splice variant activity. Recent analysis clinical specimens supports a potential biomarker aggressive cancer. Consistent with role promoting castration-­resistant disease, versatile enhancer both ligand-dependent ligand-independent mechanisms such impacts pathways reactivation advanced Distinct domains participate -independent coactivation. To provide physiologic context, we review actions elucidated gene knockout studies. This chapter describes pervasive to castration resistance. We discuss which cells exploit signaling promote activity under different hormonal milieus, are relevant Lastly, data on emerging for cancers ranging leukemias gliomas.