Lagged Coupled Changes Between White Matter Microstructure and Processing Speed in Healthy Aging: A Longitudinal Investigation.

摘要: Age-related differences in white matter (WM) microstructure have been linked to lower performance tasks of processing speed healthy older individuals. However, only few studies examined this link a longitudinal setting. These investigations limited the correlation simultaneous changes WM and speed. Still little is known about nature age-related microstructure, i.e., regionally distinct vs. global changes. In present study, we addressed these open questions by exploring whether previous were related subsequent speed: (a) 1 year later; or (b) 2 years later. Furthermore, investigated specific global. We used data from four occasions (covering 4 years) Longitudinal Healthy Aging Brain (LHAB) database project (N = 232; age range at baseline 64-86). As measure mean fractional anisotropy (FA) 10 major tracts averaged across hemispheres. Processing was measured with cognitive tasks. Statistical analyses conducted bivariate latent change score (LCS) models. found, for first time, evidence lagged couplings between preceding FA years, but not later some (anterior thalamic radiation, superior fasciculus). Our results supported notion that different regional rather than globally shared, showing declines FA, others remaining relatively stable years.