作者: Krishna A Dani , Ralph GR Thomas , Francesca M Chappell , Kirsten Shuler , Mary J MacLeod
DOI: 10.1002/ANA.22500
关键词: Cerebral infarction 、 Cerebral perfusion pressure 、 Magnetic resonance imaging 、 Perfusion 、 Cerebral blood flow 、 Stroke 、 Perfusion scanning 、 Radiology 、 Infarction 、 Medicine
摘要: Objective: Cerebral perfusion imaging with computed tomography (CT) or magnetic resonance (MR) is widely available. The optimum values to identify tissue at risk of infarction in acute stroke are unclear. We systematically reviewed CT and MR ischemic stroke. Methods: searched for papers on performed <24 hours after that assessed thresholds, mean lesion values, volumes. extracted definitions values. compared evaluated thresholds ‘‘nonviable’’/’’at risk’’ ‘‘at risk’’/’’not tissue’’ thresholds. Results: Among 7,152 papers, 69 met inclusion criteria analysis (49 20 CT), 21 (n ¼ 551), 10 266) median sample size 22, provided found multiple states, eg, risk, 18; nonviable tissue, 12; 16, no definition. Perfusion parameters varied widely; 9 different MR, 6 the threshold.’’ Median threshold up 4-fold, threshold,’’ cerebral blood flow ranged from 18 37ml/100g/min; transit time 1.8 8.3 seconds relative contralateral side. influence reperfusion duration ischemia could not be assessed. Interpretation: viability derived small numbers patients, variable methods states. Greater consistency would help determine reliable wider clinical use imaging. ANN NEUROL 2011;70:384–401