Hypercoagulability: interaction between inflammation and coagulation in familial Mediterranean fever

摘要: Familial Mediterranean fever (FMF) patients in clinical remission are reported to have increased baseline inflammation. Normal function of the natural anticoagulant pathways is particularly needed diminishing inflammatory responses. In presence subclinical inflammation, response may be exaggerated. We aimed observe anticoagulant–procoagulant status attack-free FMF patients. Twenty-seven diagnosed accordance with Tel-Hashomer criteria, and 26 healthy controls were included. All under regular colchicine treatment. Amyloidosis, autoimmunity, accompanying liver renal disease, vasculitis excluded. Predisposing factors for thrombosis not present. Acute phase reactants (APRs), anticardiolipin antibody positivity, prothrombin time (PT), activated time, thrombin (TT) d-dimer, protein C activity, resistance, free S, antithrombin, lupus anticoagulant, human fragment F 1 + 2, thrombin/antithrombin III complex analyzed all subjects. APRs comparable controls. Autoimmune markers negative all. Anti-streptolysin titers significantly different than control group. PT, TT, 2 levels from those Shortened PT decreased activity vs suggested a hypercoagulable state our The detected suggests that screening abnormal coagulation tests beneficial tracing future consequences inflammation these Studies covering larger groups verify currently observed FMF.