Pharmacokinetics of enrofloxacin and its metabolite ciprofloxacin after intravenous and oral administration of enrofloxacin in dogs

作者: K. KÜNG , J.-L. RIOND , M. WANNER

DOI: 10.1111/J.1365-2885.1993.TB00212.X

关键词: AntimicrobialCmaxActive ingredientCiprofloxacinOral administrationPharmacologyChemistryPharmacokineticsMetaboliteEnrofloxacin

摘要: … Plasma concentrations of the active ingredient enrofloxacin and its main metabolite … to those of enrofloxacin described in the veterinary literature. Mean enrofloxacin t ½λZ was 2.4 h, …

参考文章(17)
T. Bergan, A. Dalhoff, R. Rohwedder, Pharmacokinetics of ciprofloxacin. Infection. ,vol. 16, ,(1988) , 10.1007/BF01650500
Gouyette A, Pharmacokinetics: statistical moment calculations. Drug Research. ,vol. 33, pp. 173- ,(1983)
K M Yielding, J F Prescott, In vitro susceptibility of selected veterinary bacterial pathogens to ciprofloxacin, enrofloxacin and norfloxacin. Canadian Journal of Veterinary Research-revue Canadienne De Recherche Veterinaire. ,vol. 54, pp. 195- 197 ,(1990)
Krystyna Tyczkowska, Kevin M. Hedeen, David P. Aucoin, Arthur L. Aronson, High-performance liquid chromatographic method for the simultaneous determination of enrofloxacin and its primary metabolite ciprofloxacin in canine serum and prostatic tissue Journal of Chromatography B: Biomedical Sciences and Applications. ,vol. 493, pp. 337- 346 ,(1989) , 10.1016/S0378-4347(00)82739-5
J. F. M. Nouws, J. L. Grondel, A. R. Schutte, J. Laurensen, Pharmacokinetics of ciprofloxacin in carp, African catfish and rainbow trout Veterinary Quarterly. ,vol. 10, pp. 211- 216 ,(1988) , 10.1080/01652176.1988.9694173
J. F. M. Nouws, D. J. Mevius, T. B. Vree, A. M. Baars, J. Laurensen, Pharmacokinetics, renal clearance and metabolism of ciprofloxacin following intravenous and oral administration to calves and pigs. Veterinary Quarterly. ,vol. 10, pp. 156- 163 ,(1988) , 10.1080/01652176.1988.9694165
G Hoffken, H Lode, C Prinzing, K Borner, P Koeppe, Pharmacokinetics of ciprofloxacin after oral and parenteral administration. Antimicrobial Agents and Chemotherapy. ,vol. 27, pp. 375- 379 ,(1985) , 10.1128/AAC.27.3.375
K. FLAMMER, D. P. AUCOIN, D. A. WHITT, Intramuscular and oral disposition of enrofloxacin in African grey parrots following single and multiple doses Journal of Veterinary Pharmacology and Therapeutics. ,vol. 14, pp. 359- 366 ,(1991) , 10.1111/J.1365-2885.1991.TB00849.X