Targeting RANKL in metastasis.
作者： William C Dougall , Ingunn Holen , Eva González Suárez
关键词: Metastasis 、 Osteoclast 、 RANKL 、 RANK Ligand 、 Denosumab 、 Cancer cell 、 Cancer research 、 Osteolysis 、 Pathology 、 Medicine 、 Blockade
摘要: … are consistent with the expression of RANKL at sites of lung and bone metastasis (and not within subcutaneous tumors) and suggest a direct pro-metastatic role for RANKL independent …
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Pasquale Pellegrini, Alex Cordero, Marta Ines Gallego, William C. Dougall, Muñoz Purificación, Miguel Angel Pujana, Eva Gonzalez-Suarez, Constitutive activation of RANK disrupts mammary cell fate leading to tumorigenesis Stem Cells. ,vol. 31, pp. 1954- 1965 ,(2013) , 10.1002/STEM.1454
Young-Yun Kong, Hiroki Yoshida, Ildiko Sarosi, Hong-Lin Tan, Emma Timms, Casey Capparelli, Sean Morony, Antonio J. Oliveira-dos-Santos, Gwyneth Van, Annick Itie, Wilson Khoo, Andrew Wakeham, Colin R. Dunstan, David L. Lacey, Tak W. Mak, William J. Boyle, Josef M. Penninger, OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis Nature. ,vol. 397, pp. 315- 323 ,(1999) , 10.1038/16852
William C. Dougall, Molecular Pathways: Osteoclast-Dependent and Osteoclast-Independent Roles of the RANKL/RANK/OPG Pathway in Tumorigenesis and Metastasis Clinical Cancer Research. ,vol. 18, pp. 326- 335 ,(2012) , 10.1158/1078-0432.CCR-10-2507
Jian Zhang, Yi Lu, Jinlu Dai, Zhi Yao, Riko Kitazawa, Sohei Kitazawa, Xinping Zhao, Daniel E. Hall, Kenneth J. Pienta, Evan T. Keller, In vivo real-time imaging of TGF-?-induced transcriptional activation of the RANK ligand gene promoter in intraosseous prostate cancer The Prostate. ,vol. 59, pp. 360- 369 ,(2004) , 10.1002/PROS.20019
Eva Gonzalez-Suarez, Allison P. Jacob, Jon Jones, Robert Miller, Martine P. Roudier-Meyer, Ryan Erwert, Jan Pinkas, Dan Branstetter, William C. Dougall, RANK ligand mediates progestin-induced mammary epithelial proliferation and carcinogenesis Nature. ,vol. 468, pp. 103- 107 ,(2010) , 10.1038/NATURE09495
Wei Tan, Weizhou Zhang, Amy Strasner, Sergei Grivennikov, Jin Q. Cheng, Robert M. Hoffman, Michael Karin, Tumour-infiltrating regulatory T cells stimulate mammary cancer metastasis through RANKL–RANK signalling Nature. ,vol. 470, pp. 548- 553 ,(2011) , 10.1038/NATURE09707
Jun-Li Luo, Wei Tan, Jill M. Ricono, Olexandr Korchynskyi, Ming Zhang, Steven L. Gonias, David A. Cheresh, Michael Karin, Nuclear cytokine-activated IKKα controls prostate cancer metastasis by repressing Maspin Nature. ,vol. 446, pp. 690- 694 ,(2007) , 10.1038/NATURE05656
Madeline Li, Peter Fitzgerald, Gary Rodin, Evidence-Based Treatment of Depression in Patients With Cancer Journal of Clinical Oncology. ,vol. 30, pp. 1187- 1196 ,(2012) , 10.1200/JCO.2011.39.7372
Colm Morrissey, Paul L Kostenuik, Lisha G Brown, Robert L Vessella, Eva Corey, Host-derived RANKL is responsible for osteolysis in a C4-2 human prostate cancer xenograft model of experimental bone metastases BMC Cancer. ,vol. 7, pp. 148- 148 ,(2007) , 10.1186/1471-2407-7-148
Purna A. Joshi, Hartland W. Jackson, Alexander G. Beristain, Marco A. Di Grappa, Patricia A. Mote, Christine L. Clarke, John Stingl, Paul D. Waterhouse, Rama Khokha, Progesterone induces adult mammary stem cell expansion Nature. ,vol. 465, pp. 803- 807 ,(2010) , 10.1038/NATURE09091