Constitutive activation of RANK disrupts mammary cell fate leading to tumorigenesis
作者： Pasquale Pellegrini , Alex Cordero , Marta Ines Gallego , William C. Dougall , Muñoz Purificación
DOI: 10.1002/STEM.1454
关键词:
摘要: Receptor Activator of NF-kappa B (RANK) pathway controls mammary gland development in mice but its role stem cell fate remains undefined. We show that constitutive RANK signaling expands luminal and basal compartments including progenitor pools interferes with the generation CD61+ Sca1+ cells Elf5 expression. Impaired commitment upon overexpression leads to accumulation progenitors K14+K8+ bipotent formation heterogeneous tumors containing hyperplastic basal, luminal, cells. expression increases wild-type epithelia age parity, spontaneous preneoplastic lesions express accumulate In human breast tumors, high levels are also associated altered differentiation. These results suggest increased commitment, contributing carcinogenesis.
sci-hub.se 参考文章(40)
Leslie Bernstein, Epidemiology of endocrine-related risk factors for breast cancer. Journal of Mammary Gland Biology and Neoplasia. ,vol. 7, pp. 3- 15 ,(2002) , 10.1023/A:1015714305420
Katherine E Sleeman, Howard Kendrick, Alan Ashworth, Clare M Isacke, Matthew J Smalley, CD24 staining of mouse mammary gland cells defines luminal epithelial, myoepithelial/basal and non-epithelial cells Breast Cancer Research. ,vol. 8, pp. 1- 6 ,(2005) , 10.1186/BCR1371
Matthew J. Smalley, Isolation, culture and analysis of mouse mammary epithelial cells Methods of Molecular Biology. ,vol. 633, pp. 139- 170 ,(2010) , 10.1007/978-1-59745-019-5_11
Eva Gonzalez-Suarez, Allison P. Jacob, Jon Jones, Robert Miller, Martine P. Roudier-Meyer, Ryan Erwert, Jan Pinkas, Dan Branstetter, William C. Dougall, RANK ligand mediates progestin-induced mammary epithelial proliferation and carcinogenesis Nature. ,vol. 468, pp. 103- 107 ,(2010) , 10.1038/NATURE09495
Matthew Smalley, Alan Ashworth, Stem cells and breast cancer: A field in transit. Nature Reviews Cancer. ,vol. 3, pp. 832- 844 ,(2003) , 10.1038/NRC1212
Mark Shackleton, François Vaillant, Kaylene J. Simpson, John Stingl, Gordon K. Smyth, Marie-Liesse Asselin-Labat, Li Wu, Geoffrey J. Lindeman, Jane E. Visvader, Generation of a functional mammary gland from a single stem cell Nature. ,vol. 439, pp. 84- 88 ,(2006) , 10.1038/NATURE04372
C. T. Guy, M. A. Webster, M. Schaller, T. J. Parsons, R. D. Cardiff, W. J. Muller, Expression of the neu protooncogene in the mammary epithelium of transgenic mice induces metastatic disease Proceedings of the National Academy of Sciences of the United States of America. ,vol. 89, pp. 10578- 10582 ,(1992) , 10.1073/PNAS.89.22.10578
Purna A. Joshi, Hartland W. Jackson, Alexander G. Beristain, Marco A. Di Grappa, Patricia A. Mote, Christine L. Clarke, John Stingl, Paul D. Waterhouse, Rama Khokha, Progesterone induces adult mammary stem cell expansion Nature. ,vol. 465, pp. 803- 807 ,(2010) , 10.1038/NATURE09091
Mona Shehata, Andrew Teschendorff, Gemma Sharp, Nikola Novcic, I Alasdair Russell, Stefanie Avril, Michael Prater, Peter Eirew, Carlos Caldas, Christine J Watson, John Stingl, None, Phenotypic and functional characterisation of the luminal cell hierarchy of the mammary gland Breast Cancer Research. ,vol. 14, pp. 1- 19 ,(2012) , 10.1186/BCR3334
Gemma Molyneux, Felipe C. Geyer, Fiona-Ann Magnay, Afshan McCarthy, Howard Kendrick, Rachael Natrajan, Alan MacKay, Anita Grigoriadis, Andrew Tutt, Alan Ashworth, Jorge S. Reis-Filho, Matthew J. Smalley, BRCA1 Basal-like Breast Cancers Originate from Luminal Epithelial Progenitors and Not from Basal Stem Cells Cell Stem Cell. ,vol. 7, pp. 403- 417 ,(2010) , 10.1016/J.STEM.2010.07.010