Rankl Impairs Lactogenic Differentiation Through Inhibition of the Prolactin/Stat5 Pathway at Midgestation.
作者： Alex Cordero , Pasquale Pellegrini , Adrián Sanz-Moreno , Eva M. Trinidad , Jordi Serra-Musach
DOI: 10.1002/STEM.2271
关键词:
摘要: … Now we show that later in pregnancy, Rankl inhibits prolactin induced lactogenesis and terminal differentiation by interfering with Stat5 activation and expands basal and bipotent cells. …
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F. Gouilleux, H. Wakao, M. Mundt, B. Groner, Prolactin induces phosphorylation of Tyr694 of Stat5 (MGF), a prerequisite for DNA binding and induction of transcription. The EMBO Journal. ,vol. 13, pp. 4361- 4369 ,(1994) , 10.1002/J.1460-2075.1994.TB06756.X
Pasquale Pellegrini, Alex Cordero, Marta Ines Gallego, William C. Dougall, Muñoz Purificación, Miguel Angel Pujana, Eva Gonzalez-Suarez, Constitutive activation of RANK disrupts mammary cell fate leading to tumorigenesis Stem Cells. ,vol. 31, pp. 1954- 1965 ,(2013) , 10.1002/STEM.1454
Steven M Anderson, Michael C Rudolph, James L McManaman, Margaret C Neville, Key stages in mammary gland development. Secretory activation in the mammary gland: it's not just about milk protein synthesis! Breast Cancer Research. ,vol. 9, pp. 204- 204 ,(2007) , 10.1186/BCR1653
Margaret C. Neville, Thomas B. McFadden, Isabel Forsyth, Hormonal regulation of mammary differentiation and milk secretion. Journal of Mammary Gland Biology and Neoplasia. ,vol. 7, pp. 49- 66 ,(2002) , 10.1023/A:1015770423167
Matthew J. Smalley, Isolation, culture and analysis of mouse mammary epithelial cells Methods of Molecular Biology. ,vol. 633, pp. 139- 170 ,(2010) , 10.1007/978-1-59745-019-5_11
M. H. Barcellos-Hoff, M. J. Bissell, T. G. Ram, J. Aggeler, Functional differentiation and alveolar morphogenesis of primary mammary cultures on reconstituted basement membrane Development. ,vol. 105, pp. 223- 235 ,(1989) , 10.1242/DEV.105.2.223
Sibylle Geymayer, Wolfgang Doppler, Activation of NF-κB p50/p65 is regulated in the developing mammary gland and inhibits STAT5-mediated β-casein gene expression The FASEB Journal. ,vol. 14, pp. 1159- 1170 ,(2000) , 10.1096/FASEBJ.14.9.1159
B. Mulac-Jericevic, J. P. Lydon, F. J. DeMayo, O. M. Conneely, Defective mammary gland morphogenesis in mice lacking the progesterone receptor B isoform Proceedings of the National Academy of Sciences of the United States of America. ,vol. 100, pp. 9744- 9749 ,(2003) , 10.1073/PNAS.1732707100
Eva Gonzalez-Suarez, Allison P. Jacob, Jon Jones, Robert Miller, Martine P. Roudier-Meyer, Ryan Erwert, Jan Pinkas, Dan Branstetter, William C. Dougall, RANK ligand mediates progestin-induced mammary epithelial proliferation and carcinogenesis Nature. ,vol. 468, pp. 103- 107 ,(2010) , 10.1038/NATURE09495
Jiong Zhou, Renee Chehab, Josephine Tkalcevic, Matthew J Naylor, Jessica Harris, Trevor J Wilson, Sue Tsao, Irene Tellis, Silva Zavarsek, Dakang Xu, Erika J Lapinskas, Jane Visvader, Geoffrey J Lindeman, Ross Thomas, Christopher J Ormandy, Paul J Hertzog, Ismail Kola, Melanie A Pritchard, Elf5 is essential for early embryogenesis and mammary gland development during pregnancy and lactation The EMBO Journal. ,vol. 24, pp. 635- 644 ,(2005) , 10.1038/SJ.EMBOJ.7600538