Key stages in mammary gland development. Secretory activation in the mammary gland: it's not just about milk protein synthesis!

摘要: The transition from pregnancy to lactation is a critical event in the survival of newborn since all nutrient requirements infant are provided by milk. While milk contains numerous components, including proteins, that aid maintaining health infant, lactose and fat represent energy providing elements Much research date on mammary epithelial differentiation has focused upon expression protein genes, somewhat distorted view alveolar secretory activation. genes increases during at activation, whose more tightly regulated this those regulate lipid biosynthesis. sterol regulatory element binding (SREBP) family transcription factors recognized as regulating fatty acid cholesterol We propose SREBP1 regulator activation with regard biosynthesis, manner responds diet, serine/threonine kinase Akt influences process, resulting highly efficient synthetic organ able support nutritional needs newborn.