Monoterpene indole alkaloids from the stem bark of Mitragyna diversifolia and their acetylcholine esterase inhibitory effects.
作者： Xing-Fen Cao , Jun-Song Wang , Xiao-Bing Wang , Jun Luo , Hong-Ying Wang
DOI: 10.1016/J.PHYTOCHEM.2013.10.002
关键词: Acetylcholinesterase 、 Mitragyna diversifolia 、 Indole test 、 Stereochemistry 、 Stem bark 、 Acetylcholine esterase 、 Rubiaceae 、 Chemistry 、 Monoterpene 、 Inhibitory postsynaptic potential
摘要: Abstract Five monoterpene indole alkaloids, mitradiversifoline, with a unique rearranged skeleton, specionoxeine- N (4)-oxide, 7-hydroxyisopaynantheine, 3-dehydropaynantheine, and 3-isopaynantheine- 10 known ones, were isolated from Mitragyna diversifolia . All the isolates evaluated for their inhibition of acetylcholinesterase activities, four showed moderate IC 50 values 4.1, 5.2, 10.2, 10.3 μM, respectively.
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