HOXD-AS1 functions as an oncogenic ceRNA to promote NSCLC cell progression by sequestering miR-147a

摘要: Abstract Non-small cell lung cancer (NSCLC) is one of the most common malignancies worldwide, and it occurs at a higher frequency in males. HOXD-AS1, an important cancer-associated long noncoding RNA (lncRNA), contributes to development progression several cancers. However, exact roles HOXD-AS1 NSCLC are still unknown. Here, we investigated underlying mechanisms human tissues. We found that lncRNA was specifically upregulated (P<0.001) tissues promoted growth by targeting miR-147a. Moreover, expression positively correlated with clinical pathologic characteristics (tumor size, P=0.006; tumor stage, P=0.044; recurrence, P=0.031) survival rate (P=0.003). knockdown reduced proliferation apoptosis cells. The dual-luciferase reporter assay showed could negatively regulate miR-147a inhibition abrogated effect on Furthermore, regulated pRB (a suppressor protein) Taken together, our data indicated might be oncogenic promotes therapeutic target NSCLC.