Melanocortin-4 Receptors Expressed by Cholinergic Neurons Regulate Energy Balance and Glucose Homeostasis

作者: Jari Rossi , Nina Balthasar , David Olson , Michael Scott , Eric Berglund

DOI: 10.1016/J.CMET.2011.01.010

关键词: MelanocortinCholinergic neuronEndocrinologyInsulinGlucose homeostasisMelanocortinsHomeostasisDorsal motor nucleusHyperinsulinemiaBiologyInternal medicine

摘要: … that both cholinergic sympathetic and parasympathetic preganglionic neurons express MC4-… of MC3R/MC4R nonselective agonist MTII and antagonist SHU9119 into the fourth ventricle …

参考文章(49)
Christian Vaisse, Karine Clement, Bernard Guy-Grand, Philippe Froguel, A frameshift mutation in human MC4R is associated with a dominant form of obesity Nature Genetics. ,vol. 20, pp. 113- 114 ,(1998) , 10.1038/2407
Hongyan Liu, Toshiro Kishi, Aaron G. Roseberry, Xiaoli Cai, Charlotte E. Lee, Jason M. Montez, Jeffrey M. Friedman, Joel K. Elmquist, Transgenic Mice Expressing Green Fluorescent Protein under the Control of the Melanocortin-4 Receptor Promoter The Journal of Neuroscience. ,vol. 23, pp. 7143- 7154 ,(2003) , 10.1523/JNEUROSCI.23-18-07143.2003
Michael W. Schwartz, Stephen C. Woods, Daniel Porte, Randy J. Seeley, Denis G. Baskin, Central nervous system control of food intake Nature. ,vol. 404, pp. 661- 671 ,(2000) , 10.1038/35007534
Airu S. Chen, Joseph M. Metzger, Myrna E. Trumbauer, Xiao-ming Guan, Hong Yu, Easter G. Frazier, Donald J. Marsh, Michael J. Forrest, Shobhna Gopal-Truter, Jill Fisher, Ramon E. Camacho, Alison M. Strack, Theodore N. Mellin, D. Euan MacIntyre, Howard Y. Chen, Lex H.T. Van der Ploeg, Role of the melanocortin-4 receptor in metabolic rate and food intake in mice. Transgenic Research. ,vol. 9, pp. 145- 154 ,(2000) , 10.1023/A:1008983615045
Giles S.H. Yeo, I. Sadaf Farooqi, Shiva Aminian, David J. Halsall, Richard G. Stanhope, Stephen O'Rahilly, A frameshift mutation in MC4R associated with dominantly inherited human obesity Nature Genetics. ,vol. 20, pp. 111- 112 ,(1998) , 10.1038/2404
Wei Fan, Shaun F. Morrison, Wei-Hua Cao, Pinxuan Yu, Thermogenesis activated by central melanocortin signaling is dependent on neurons in the rostral raphe pallidus (rRPa) area Brain Research. ,vol. 1179, pp. 61- 69 ,(2007) , 10.1016/J.BRAINRES.2007.04.006
I. Sadaf Farooqi, Julia M. Keogh, Giles S.H. Yeo, Emma J. Lank, Tim Cheetham, Stephen O'Rahilly, Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene. The New England Journal of Medicine. ,vol. 348, pp. 1085- 1095 ,(2003) , 10.1056/NEJMOA022050
Roger D Cone, Anatomy and regulation of the central melanocortin system. Nature Neuroscience. ,vol. 8, pp. 571- 578 ,(2005) , 10.1038/NN1455
Carol F. Elias, Charlotte Lee, Joseph Kelly, Carl Aschkenasi, Rexford S. Ahima, Pastor R. Couceyro, Michael J. Kuhar, Clifford B. Saper, Joel K. Elmquist, Leptin Activates Hypothalamic CART Neurons Projecting to the Spinal Cord Neuron. ,vol. 21, pp. 1375- 1385 ,(1998) , 10.1016/S0896-6273(00)80656-X