Associations between a common variant near the MC4R gene and serum triglyceride levels in an obese pediatric cohort

摘要: Polymorphisms near the MC4R gene may be related to an increased risk for obesity, but studies of variations in this and its relation cardiometabolic profiles food intake are scarce controversial. The aim study is evaluate influence variants rs12970134 rs17782313 intake, binge eating (BE) behavior, anthropometric parameters, body composition, metabolic profile, factors obese children adolescents. This a cross-sectional that included We evaluated anthropometric, parameters factors, including hypertension, impaired fasting glucose, hypertriglyceridemia, low HDL-cholesterol. BE was assessed through scale, 24-h recall used total caloric percentage macronutrients types dietary fat. were genotyped using TaqMan assay. To assess magnitude risk, logistic regression adjusted Z-BMI, age, gender performed, adopting significance level 0.05. 518 subjects (52.1 % girls, 12.7 ± 2.7 years old, Z-BMI = 3.24 0.57). Carriers variant exhibit triglyceride levels (108 48 vs. 119 54, p 0.034) hypertriglyceridemia (OR 1.985, 95 CI 1.288–3.057, 0.002). There no association SNP with clinical, metabolic, or nutritional parameters. did not presence BE. associated