Environmental enrichment aides in functional recovery following unilateral controlled cortical impact of the forelimb sensorimotor area however intranasal administration of nerve growth factor does not
作者： Jennica Young , Timothy Pionk , Ivy Hiatt , Katalin Geeck , Jeffrey S. Smith
DOI: 10.1016/J.BRAINRESBULL.2015.04.003
关键词: Anesthesia 、 Functional recovery 、 Forelimb 、 Nerve growth factor 、 Nasal administration 、 Lesion 、 Traumatic brain injury 、 Sensorimotor cortex 、 Environmental enrichment 、 Psychology
摘要: Abstract Purpose An injury to the forelimb sensorimotor cortex results in impairment of motor function animals. Recent research has suggested that intranasal administration nerve growth factor (NGF), a protein naturally found brain, and placement into enriched environments (EE) improves cognitive after traumatic brain (TBI). The purpose this study was determine whether NGF, EE, or combination both beneficial recovery following TBI. Results Uninjured animals had fewer foot faults than injured animals, displaying lesion effect. Injured housed EE were shown have not they received NGF. also displayed an increased reliance on non-impaired limb further validating Conclusion is effective treatment Intranasal NGF be for functional
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