Role of Nerve Growth Factor in Plasticity of Forebrain Cholinergic Neurons.

摘要: Neuronal plastic rearrangements during the development and functioning of neurons are largely regulated by trophic factors, including nerve growth factor (NGF). NGF is also involved in pathogenesis Alzheimer's disease. In brain, produced structures innervated basal forebrain cholinergic retrogradely transported along axons to bodies neurons. essential for normal forebrain; it affects formation dendritic tree modulates activities choline acetyltransferase acetylcholinesterase The effect mediated through its interactions with TrkA p75 receptors. Experimental clinical studies have shown that brain levels altered various pathologies. However, therapeutic use limited poor ability penetrate blood-brain barrier, adverse side effects due pleiotropic action this factor, possibility immune response NGF. For reason, gene therapy methods treating deficit-associated pathologies particular interest. Another approach creation low molecular weight mimetics would interact corresponding receptors display high biological activity but be free unfavorable