Paternal Age and Offspring Congenital Heart Defects: A National Cohort Study

摘要: Paternal age has been associated with offspring congenital heart defects (CHDs), which might be caused by increased mutations in the germ cell line because of cumulated replications. Empirical evidences, however, remain inconclusive. Furthermore, it is unknown whether all subtypes CHDs are affected paternal age. We aimed to explore relationship between and risk its five common using national register data Denmark. A total 1 893 899 singletons born Denmark from 1977 2008 were included this national-based cohort study. Cox’s proportion hazards model robust sandwich estimate option was used ratio (95% confidence interval) for associations CHDs, as well (patent ductus arteriosus (PDA), ventricular septal defect (VSD), atrial (ASD), tetralogy fallot (TOF) coarctation aorta (CoA)). did not observe an overall association CHDs. However, compared 25–29 years, older than 45 years a 69% PDA (HR45+ = 1.69, 95%CI:1.17–2.43). observed similar results when subanalyses restricted children mothers 27–30 old. After taking into consideration maternal age, our suggested that advanced prevalence one subtype namely patent (PDA).