Ovarian function suppression with the gonadotrophin-releasing hormone (GnRH) analogue goserelin in premenopausal advanced breast cancer.
作者： Emilio Bajetta , Luigi Celio , Nicoletta Zilembo , Aldo Bono , Domenico Galluzzo
DOI: 10.1177/030089169408000105
关键词: Hormone 、 Endocrine system 、 Oncology 、 Survival analysis 、 Goserelin 、 Castration 、 Internal medicine 、 Cancer 、 Oophorectomy 、 Breast cancer 、 Medicine
摘要: Aims and background Goserelin is a gonadotrophin-releasing hormone (GnRH) analogue that induces the suppression of gonadal steroidogenesis, it could therefore be medical alternative to irreversible surgical castration. We report clinical endocrine results from 40 goserelin-treated premenopausal patients with advanced breast cancer. Methods A depot formulation drug (3.6 mg s.c.) was administered fortnightly for first 4 doses, monthly thereafter. Gonadotrophins estradiol (E2) levels were measured before at specific times during treatment. Results Objective responses observed in 17 38 evaluable (45%), six whom achieved complete remission. The best on soft tissues (65%). Castration E2 all patients. Conclusions Our confirm goserelin as effective oophorectomy
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