Medicinal chemistry of oxazines as promising agents in drug discovery

作者: Dhafer S Zinad , Ahmed Mahal , Ranjan K Mohapatra , Ashish K Sarangi , Mohammad Rizki Fadhil Pratama

DOI: 10.1111/CBDD.13633

关键词: Drug discoveryOxazinesAntimicrobialCombinatorial chemistryDrugChemistry

摘要: … review on the synthesis of oxazine derivatives and their pharmaceutical and biological … recuced the levels of Aβ in the AD brain. The derivative 76 was confirmed as a potent (IC 50 …

参考文章(139)
Liang Fang, Hua Zuo, Zhu-Bo Li, Xiao-Yan He, Li-Ying Wang, Xiao Tian, Bao-Xiang Zhao, Jun-Ying Miao, Dong-Soo Shin, None, Synthesis of benzo[b][1,4]oxazin-3(4H)-ones via smiles rearrangement for antimicrobial activity Medicinal Chemistry Research. ,vol. 20, pp. 670- 677 ,(2011) , 10.1007/S00044-010-9360-Z
Marshall Nj, Holt Sj, Goodwin Cj, A critical assessment of the use of microculture tetrazolium assays to measure cell growth and function. Growth regulation. ,vol. 5, pp. 69- 84 ,(1995)
V. Srinivas, Chakrabhavi Dhananjaya Mohan, C.P. Baburajeev, Shobith Rangappa, Swamy Jagadish, Julian E. Fuchs, Alexey Yu. Sukhorukov, Chandra, Daniel J. Mason, Kothanahally Shivaramu Sharath Kumar, Mahendra Madegowda, Andreas Bender, Basappa, Kanchugarakoppal Subbegowda Rangappa, Synthesis and characterization of novel oxazines and demonstration that they specifically target cyclooxygenase 2. Bioorganic & Medicinal Chemistry Letters. ,vol. 25, pp. 2931- 2936 ,(2015) , 10.1016/J.BMCL.2015.05.047
Chia-Chung Lee, Fei-Lan Liu, Chun-Liang Chen, Tsung-Chih Chen, Feng-Cheng Liu, Ahmed Atef Ahmed Ali, Deh-Ming Chang, Hsu-Shan Huang, Novel inhibitors of RANKL-induced osteoclastogenesis: Design, synthesis, and biological evaluation of 6-(2,4-difluorophenyl)-3-phenyl-2H-benzo[e][1,3]oxazine-2,4(3H)-diones Bioorganic & Medicinal Chemistry. ,vol. 23, pp. 4522- 4532 ,(2015) , 10.1016/J.BMC.2015.06.007
Young-Goo Kang, Chan-Yong Park, Hongsuk Shin, Ramandeep Singh, Garima Arora, Chan-mo Yu, Ill Young Lee, None, Synthesis and anti-tubercular activity of 2-nitroimidazooxazines with modification at the C-7 position as PA-824 analogs. Bioorganic & Medicinal Chemistry Letters. ,vol. 25, pp. 3650- 3653 ,(2015) , 10.1016/J.BMCL.2015.06.060
Yousuke KATSURA, Shigetaka NISHINO, Hisashi TAKASUGI, Studies on Antiulcer Drugs. I. Synthesis and Antiuler Activities of Imidazo[1, 2-a]pyridinyl-2-oxobenzoxazolidines-3-oxo-2H-1, 4-benzoxazines and Related Compounds Chemical & Pharmaceutical Bulletin. ,vol. 39, pp. 2937- 2943 ,(1991) , 10.1248/CPB.39.2937
Hanumantharayappa Bharathkumar, Chakrabhavi Dhananjaya Mohan, Shobith Rangappa, Taehee Kang, H. K. Keerthy, Julian E. Fuchs, Nam Hoon Kwon, Andreas Bender, Sunghoon Kim, Basappa Basappa, Kanchugarakoppal S. Rangappa, Screening of quinoline, 1,3-benzoxazine, and 1,3-oxazine-based small molecules against isolated methionyl-tRNA synthetase and A549 and HCT116 cancer cells including an in silico binding mode analysis Organic and Biomolecular Chemistry. ,vol. 13, pp. 9381- 9387 ,(2015) , 10.1039/C5OB00791G
Xiaojin Li, Ujjini H. Manjunatha, Michael B. Goodwin, John E. Knox, Christopher A. Lipinski, Thomas H. Keller, Clifton E. Barry, Cynthia S. Dowd, Synthesis and antitubercular activity of 7-(R)- and 7-(S)-methyl-2-nitro-6-(S)-(4-(trifluoromethoxy)benzyloxy)-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazines, analogues of PA-824. Bioorganic & Medicinal Chemistry Letters. ,vol. 18, pp. 2256- 2262 ,(2008) , 10.1016/J.BMCL.2008.03.011
Angeliki P. Kourounakis, Christos Charitos, Eleni A. Rekka, Panos N. Kourounakis, Lipid-Lowering (Hetero)Aromatic Tetrahydro-1,4-Oxazine Derivatives with Antioxidant and Squalene Synthase Inhibitory Activity Journal of Medicinal Chemistry. ,vol. 51, pp. 5861- 5865 ,(2008) , 10.1021/JM800663W
W. Oppolzer, K. Bättig, T. Hudlicky, A total synthesis of (±)-isocomene and (±) β-isocomene by an intramolecular ene reaction Tetrahedron. ,vol. 37, pp. 4359- 4364 ,(1981) , 10.1016/0040-4020(81)80001-4