Design, synthesis, and biological evaluation of new quinoline-based heterocyclic derivatives as novel antibacterial agents

摘要: A novel series of quinolone-based heterocyclic derivatives including thiadiazine, thiadiazoles, and triazole were synthesized their in vitro antibacterial activity against Gram-positive Gram-negative bacteria evaluated. Newly have been obtained good yields ranging from 65 to 80%. The characterized structures identified using spectroscopic analysis NMR, FT-IR, mass techniques. Most compounds exhibited moderate-to-good all four bacterial strains are significantly more active than ampicillin. Compounds showed relatively anti-bacterial compared moderate other compounds. results herein important for further structure modifications quinoline bearing moiety the exploitation therapeutic potential as agents.