Impact of vitamin D deficiency on the clinical and biochemical phenotype in women with sporadic primary hyperparathyroidism

摘要: The purpose of the study was to evaluate relationship between serum 25(OH)D and clinical phenotype in 215 consecutive Italian Caucasian women with sporadic primary hyperparathyroidism (PHPT) not taking vitamin D supplements. performed at a single tertiary center. PHPT-related manifestations, 25(OH)D, other parameters calcium metabolism bone mineral density (BMD) by DXA were recorded. Serum negatively correlated age (r = -0.18; P = 0.006), BMI (r = -0.20; P = 0.002), PTH (r = -0.21; P = 0.001), bone-specific alkaline phosphatase (BSAP) (r = -0.27; P < 0.001), eGFR (r = -0.22; P = 0.01), positively creatinine 1/3 distal radius BMD (R-BMD; r = 0.17; P = 0.015). In multivariate regression analysis, remained significantly P = 0.005), (r = -0.23; P = 0.049), (r = -0.01; P = 0.023), BSAP P = 0.023) (r = -0.09; but R-BMD. 25(OHD) higher patients nephrolithiasis than those without (18.5 ± 8.8 vs. 15.6 ± 8.0 ng/ml; P = 0.029), whereas no difference found fractured unfractured (16.8 ± 9.3 16.0 ± 7.7; P = 0.663). There statistically significant inverse correlation status [defined quartiles measured values as well commonly accepted cutoffs 25(OH)D] severity disease, reflected BSAP, meeting latest guidelines for parathyroidectomy. conclusion, low is associated some features reflecting more severe biochemical PHPT