MECHANISMS IN ENDOCRINOLOGY: Kidney involvement in patients with primary hyperparathyroidism: an update on clinical and molecular aspects

摘要: Primary hyperparathyroidism (PHPT) is the third most common endocrine disease. Kidney a target of both chronic elevated PTH and calcium in PHPT. The classic PHPT complications symptomatic kidney stones nephrocalcinosis have become rare current presentation asymptomatic with uncertain long-lasting progression. Nonetheless, routine use imaging biochemical determinations revealed frequent occurrence stones, hypercalciuria reduced function patients. Though pathogenesis far from being elucidated, associated renal function, terms estimated glomerular filtration rate, related increased morbidity mortality. In last decade, effort Disease: Improving Global Outcomes (KDIGO) panel experts highlighted that even mild reduction risk cardiovascular These considerations provided basis for Fourth Workshop recommendations more extensive diagnostic workout about features wider criteria parathyroid surgery including Moreover, involvement likely to be affected by variants genes coding key molecules regulating ions handling; these might clinical relevance should considered during follow-up. Finally, effects medical treatment on are reviewed.