Prevalence and characteristics of metabolic syndrome in primary hyperparathyroidism.

摘要: Aims: Primary hyperparathyroidism (pHPT) is characterized by an increased frequency of glucose tolerance abnormalities associated with insulin resistance. Few studies evaluated the prevalence metabolic syndrome (MetS) in pHPT and whether there are differences between asymptomatic patients symptomatic ones. Thus, we sought to investigate MetS comparison Italian population. Subjects methods: We conducted a retrospective chart review 294 patients, these 154 [age (mean±SD) 58.7±13.3 yr, body mass index 25.6±4.8 kg/m2; serum calcium (11.3±1.2 mg/dl) 2.8±0.3 mmol/l; PTH 234.8±224.3 ng/l] met inclusion criteria. A modified National Cholesterol Educational Program (NCEP)/Adult Treatment Panel III (ATP III) definition was used. Prevalence compared that reported for population (Progetto Cuore Study). Results: The (34/154, 22.1%) similar general Asymptomatic were older (62.1±12.7 vs 56.4±13.2 p<0.008) showed higher than ones (30.2% 16.5%, p<0.045). Moreover nephrolitiasis or overt bone disease not different MetS+pHPT MetS-pHPT, whereas femoral mineral density (BMD) (p<0.003). In logistic regression model age BMD independent predictors MetS. Conclusions: population, thus, its diagnosis appropriate tool identify additional cardiovascular risk related pHPT. Difference affects patients.