Analysis of the association of HOTAIR single nucleotide polymorphism (rs920778) and risk of cervical cancer.
作者： Haifeng Qiu , Qiuli Liu , Juan Li , Xiujuan Wang , Yuan Wang
DOI: 10.1111/APM.12550
关键词: Cervical cancer 、 Tumor progression 、 Allele 、 Single-nucleotide polymorphism 、 Genotype 、 HOTAIR 、 Oncology 、 Bioinformatics 、 Biology 、 SNP 、 Odds ratio 、 Internal medicine
摘要: Abstract We recently demonstrated that overexpression of HOTAIR (Hox transcript antisense intergenic RNA) was associated with tumor progression and radio-resistance in human cervical cancer. Considering the single nucleotide polymorphism (SNP) rs920778 (C>T) could influence expression cancer predisposition other malignancies, we herein investigated association between status susceptibility a Chinese population. Using specific TaqMan PCR assay, genotyped 215 patients 430 age-matched healthy controls. As shown our data, TT genotype significantly correlated upregulation (p = 0.008). Compared control, T allele notably indicated much higher risk [TT genotype: odds ratio (OR) = 2.186, 95% confidence interval (CI) = 1.378-3.466, p = 0.003; allele: OR = 1.556, CI = 1.221-1.981]. In addition, also found advanced stage (p = 0.039), highly histological grade (p = 0.013), lympho node metastasis (p < 0.001) positive infection high HPV (p < 0.001). Among who underwent concurrent chemo-radiotherapy, carriers present resistance to combination EBRT + ICBT + cisplatin (p = 0.023). conclusion, firstly reported susceptibility. Moreover, might be potent prognostic marker patients.
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