A functional lncRNA HOTAIR genetic variant contributes to gastric cancer susceptibility

摘要: Long noncoding RNA (lncRNA) HOX transcript antisense (HOTAIR) acts as an oncogene in gastric cancer development. HOTAIR could induce genome-wide retargeting of polycomb-repressive complex 2, trimethylates histone H3 lysine-27 (H3K27me3) and deregulation multiple downstream genes. Additionally, the ceRNA miR-331–3p, may modulate HER2 cells. We hypothesized that functional single nucleotide polymorphisms (SNP) affect expression and/or its function and, thus, risk. examined association between three haplotype-tagging SNPs (htSNP) across whole locus risk well relevance a susceptibility SNP rs920778. Genotypes were determined two independent hospital-based case-control sets consisted 800 patients 1600 controls. The allele-specific regulation on by rs920778 was vitro vivo. found TT carriers had 1.66- 1.87-fold increased Jinan Huaian populations compared with CC (P = 4.2 × 10−4 6.5 × 10−5). During inspecting SNP, we observed allelic both cell lines tissue samples, higher among T allele carriers. These findings elucidate genetic variants influencing lncRNA explain portion basis. © 2015 Wiley Periodicals, Inc.