Mouse models of gastric tumors: Wnt activation and PGE2 induction
作者： Hiroko Oshima , Masanobu Oshima
DOI: 10.1111/J.1440-1827.2010.02567.X
关键词: Chronic gastritis 、 Cancer 、 Biology 、 Pathology 、 Signal transduction 、 Carcinogenesis 、 Wnt signaling pathway 、 Metaplasia 、 Bone morphogenetic protein 、 Gastric mucosa 、 Pathology and Forensic Medicine 、 General Medicine
摘要: Accumulating evidence has suggested that cooperation of oncogenic activation and the host responses is important for cancer development. In gastric cancer, Wnt signaling appears to be a major pathway causes tumorigenesis. chronic gastritis caused by Helicobacter pylori infection, cyclooxigenase-2 induces prostaglandin E(2) (PGE(2)) biosythesis, which plays an role in We constructed series mouse models investigated each epithelial cells suppresses differentiation, development preneoplastic lesions. On other hand, induction PGE(2) mucosa spasmolytic polypeptide-expressing metaplasia (SPEM), possible metaplasia. Importantly, simultaneous pathways leads dysplastic tumor Moreover, also promotes hamartoma when bone morphogenetic protein (BMP) suppressed. These results indicate alteration or BMP impairs accelerates formation regardless types pathways. review phenotypes gene expression profiles respective models, discuss
sci-hub.se 参考文章(92)
James R. Goldenring, Sachiyo Nomura, Insights into the Development of Preneoplastic Metaplasia: Spasmolytic Polypeptide-Expressing Metaplasia and Oxyntic Atrophy Springer, New York, NY. pp. 361- 375 ,(2009) , 10.1007/978-0-387-69182-4_13
Emad M. El-Omar, Role of Host Genetic Susceptibility in the Pathogenesis of Gastric Cancer Springer, New York, NY. pp. 235- 250 ,(2009) , 10.1007/978-0-387-69182-4_9
Poulsom R, Playford Rj, Wright Na, Wright Na, Joshi, Lee, Goldenring, Schmidt Ph, Identification of a metaplastic cell lineage associated with human gastric adenocarcinoma. Laboratory Investigation. ,vol. 79, pp. 639- 646 ,(1999)
Wei-Hao Sun, Roles of Helicobacter pylori infection and cyclooxygenase-2 expression in gastric carcinogenesis World Journal of Gastroenterology. ,vol. 10, pp. 2809- 2813 ,(2004) , 10.3748/WJG.V10.I19.2809
Andrew S. Giraud, Louise M. Judd, Genetic Models of Gastric Cancer in the Mouse Springer, New York, NY. pp. 483- 512 ,(2009) , 10.1007/978-0-387-69182-4_19
Thun Mj, Calle Ee, Namboodiri Mm, Flanders Wd, Heath Cw, Aspirin Use and Risk of Fatal Cancer Cancer Research. ,vol. 53, pp. 1322- 1327 ,(1993)
Carlos A. González, Núria Sala, Gabriel Capellá, Genetic susceptibility and gastric cancer risk International Journal of Cancer. ,vol. 100, pp. 249- 260 ,(2002) , 10.1002/IJC.10466
B.S. Fletcher, D.A. Kujubu, D.M. Perrin, H.R. Herschman, Structure of the mitogen-inducible TIS10 gene and demonstration that the TIS10-encoded protein is a functional prostaglandin G/H synthase. Journal of Biological Chemistry. ,vol. 267, pp. 4338- 4344 ,(1992) , 10.1016/S0021-9258(18)42840-2
James R. Howe, Jennifer L. Bair, Mohamed G. Sayed, Mary E. Anderson, Frank A. Mitros, Gloria M. Petersen, Victor E. Velculescu, Giovanni Traverso, Bert Vogelstein, Germline mutations of the gene encoding bone morphogenetic protein receptor 1A in juvenile polyposis Nature Genetics. ,vol. 28, pp. 184- 187 ,(2001) , 10.1038/88919
Andrew M Lowy, Amod Sarnaik, On Ja Kim, Joanna Groden, Jiang Wang, Cecilia Fenoglio-Preiser, Jack MacDonald, Wilson M Clements, beta-Catenin mutation is a frequent cause of Wnt pathway activation in gastric cancer. Cancer Research. ,vol. 62, pp. 3503- 3506 ,(2002)