Identification of a metaplastic cell lineage associated with human gastric adenocarcinoma.

摘要: Metaplastic cell lineages arising in response to chronic injury are precursors for the evolution of dysplasia and adenocarcinoma. Although a subtype intestinal metaplasia has been associated with gastric adenocarcinoma, link between this lineage adenocarcinoma remained unclear. Wang et al (1998) have reported that an aberrant metaplastic morphological characteristics similar Brunner's glands duodenum develops fundic mucosa mice infected Helicobacter felis. This expresses trefoil peptide spasmolytic polypeptide (SP). Given epidemiological association species infection cancer, we hypothesized SP-expressing (SPEM) may represent precursor or appear commensurate The SPEM was present 68% biopsies from patients Helicobacterpylori-associated gastritis, but absent without H. pylori infection. In review archival samples 22 resected adenocarcinomas, found 91% cases, typically located adjacent carcinoma areas dysplasia. Importantly, 59% resections showed SP immunoreactivity within dysplastic cells. These data indicate strong both