Neuronal regeneration in a zebrafish model of adult brain injury
作者： N. Kishimoto , K. Shimizu , K. Sawamoto
DOI: 10.1242/DMM.007336
关键词: Neuroscience 、 TBR1 、 Cerebrum 、 Forebrain 、 Anatomy 、 Neural stem cell 、 Zebrafish 、 Biology 、 Subventricular zone 、 Traumatic brain injury 、 Neurogenesis
摘要: Neural stem cells in the subventricular zone (SVZ) of adult mammalian forebrain are a potential source neurons for neural tissue repair after brain insults such as ischemic stroke and traumatic injury (TBI). Recent studies show that neurogenesis ventricular (VZ) zebrafish telencephalon has features common with SVZ. Here, we established model to study injury-induced brain. We possesses remarkable capacity neuronal regeneration. Telencephalon prompted proliferation precursor (NPCs) VZ injured hemisphere, compared contralateral hemisphere. The distribution NPCs, viewed by BrdU labeling ngn1-promoter-driven GFP, suggested they migrated laterally reached site via subpallium pallium. number NPCs reaching significantly decreased when fish were treated an inhibitor γ-secretase, component Notch signaling pathway, suggesting mechanisms at least partly conserved between mammals. differentiated into mature regions surrounding within week injury. Most these expressed T-box protein (Tbr1), had adopted normal fate this region. These results suggest telencephalic contributes recovery following zebrafish, is useful regenerative medicine.
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biologists.org参考文章(70)
G. Kempermann, Neuronal stem cells and adult neurogenesis. Ernst Schering Research Foundation workshop. ,vol. 2002, pp. 17- 28 ,(2002) , 10.1007/978-3-662-04816-0_2
Haitham Salman, Pritam Ghosh, Steven G. Kernie, Subventricular zone neural stem cells remodel the brain following traumatic injury in adult mice. Journal of Neurotrauma. ,vol. 21, pp. 283- 292 ,(2004) , 10.1089/089771504322972077
Arturo Alvarez-Buylla, Jose Manuel Garcı́a-Verdugo, Neurogenesis in adult subventricular zone. The Journal of Neuroscience. ,vol. 22, pp. 629- 634 ,(2002) , 10.1523/JNEUROSCI.22-03-00629.2002
Christopher J. Phiel, Christina A. Wilson, Virginia M.-Y. Lee, Peter S. Klein, GSK-3α regulates production of Alzheimer's disease amyloid-β peptides Nature. ,vol. 423, pp. 435- 439 ,(2003) , 10.1038/NATURE01640
Katsuko Kosaka, Yusuke Aika, Kazunori Toida, Claus W. Heizmann, Willi Hunziker, David M. Jacobowitz, Ikuko Nagatsu, Peter Streit, Theo J. Visser, Toshio Kosaka, Chemically defined neuron groups and their subpopulations in the glomerular layer of the rat main olfactory bulb Neuroscience Research. ,vol. 23, pp. 73- 88 ,(1995) , 10.1016/0168-0102(95)90017-9
Martin März, Prisca Chapouton, Nicolas Diotel, Colette Vaillant, Birgit Hesl, Masanari Takamiya, Chen Sok Lam, Olivier Kah, Laure Bally-Cuif, Uwe Strähle, Heterogeneity in progenitor cell subtypes in the ventricular zone of the zebrafish adult telencephalon. Glia. ,vol. 58, pp. 870- 888 ,(2010) , 10.1002/GLIA.20971
Günther KH Zupanc, Marianne M Zupanc, New neurons for the injured brain: mechanisms of neuronal regeneration in adult teleost fish. Regenerative Medicine. ,vol. 1, pp. 207- 216 ,(2006) , 10.2217/17460751.1.2.207
Nikki L Sundholm-Peters, Helen K. C Yang, Gwendolyn E Goings, Avery S Walker, Francis G Szele, Subventricular zone neuroblasts emigrate toward cortical lesions. Journal of Neuropathology and Experimental Neurology. ,vol. 64, pp. 1089- 1100 ,(2005) , 10.1097/01.JNEN.0000190066.13312.8F
Sorcha C Clint, Günther K.H Zupanc, Neuronal regeneration in the cerebellum of adult teleost fish, Apteronotus leptorhynchus: guidance of migrating young cells by radial glia. Developmental Brain Research. ,vol. 130, pp. 15- 23 ,(2001) , 10.1016/S0165-3806(01)00193-6
Patrick Blader, Charles Plessy, Uwe Strähle, Multiple regulatory elements with spatially and temporally distinct activities control neurogenin1 expression in primary neurons of the zebrafish embryo Mechanisms of Development. ,vol. 120, pp. 211- 218 ,(2003) , 10.1016/S0925-4773(02)00413-6