Pathologic role of dietary advanced glycation end products in cardiometabolic disorders, and therapeutic intervention

摘要: Reactive derivatives from nonenzymatic glucose-protein condensation reactions, as well lipids and nucleic acids exposed to reducing sugars, form a heterogeneous group of irreversible adducts called AGEs (advanced glycation end products). The process begins with the conversion reversible Schiff base more stable, covalently bound Amadori rearrangement products. Over course days weeks, these products undergo further reactions irreversibly cross-linked macroprotein known AGEs. formation accumulation have been progress in physiological aging at an accelerated rate under hyperglycemic oxidative stress conditions. There is growing evidence that play pathologic role numerous disorders. Indeed, and/or cross-linking modification circulating or organic matrix proteins by senescence moieties deteriorate their function structural integrity multiple organ systems. Moreover, elicit inflammatory through interaction receptor for advanced variety cells, thereby contributing development progression various aging- diabetes-related disorders, such cardiovascular disease, chronic kidney insulin resistance, Alzheimer's disease. Recently, diet has recognized major environmental source could cause proinflammatory damage vivo. Therefore, this review summarizes pathophysiological dietary health especially focusing on cardiometabolic We also discuss potential utility targeting exogenously derived therapeutic intervention.