Comparison of metastatic disease after local tumour treatment with radiotherapy or surgery in various tumour models

摘要: Spontaneous metastases in lymph nodes and/or the lung were obtained after tumour cell inoculation of four mouse tumours and one rat into foot-pads syngeneic animals or their F1 hybrids. Following local radiotherapy with doses 45–80 Gy, significantly more mice died than following amputation tumour-bearing foot when 2661 carcinoma was involved. No significant difference observed these treatments for other tumours. The enhancement metastastic growth seems not to be due incomplete killing cells foot. presence irradiated normal structures tissue promoted outgrowth which outside radiation field at time treatment. Evidently, even under similar experimental conditions, may enhance from some others.