Myc inhibition is effective against glioma and reveals a role for Myc in proficient mitosis
作者： Daniela Annibali , Jonathan R. Whitfield , Emilia Favuzzi , Toni Jauset , Erika Serrano
DOI: 10.1038/NCOMMS5632
关键词: Cancer 、 Cell growth 、 Apoptosis 、 Mechanism of action 、 Astrocytoma 、 Biology 、 Mitosis 、 Proto-Oncogene Proteins c-myc 、 Cancer research 、 Glioma
摘要: Myc has been implicated in the development of multiple types cancer. Here, authors explore therapeutic potential and mechanism action inhibition mouse human models glioblastoma, an aggressive type tumour that is often resistant to conventional therapy.
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HU Yu-hua, WU Jian-liang, Chen Ze, Kong Hai-bo, Kong Shi-qi, Targeting c-Myc on cell growth and vascular endothelial growth factor expression in IN500 glioblastoma cells. Chinese Medical Journal. ,vol. 125, pp. 2025- 2031 ,(2012)
Jana Karaskova, David H. Gutmann, Luba Roncari, Luba Roncari, Patrick Shannon, Andras Nagy, Abhijit Guha, Abhijit Guha, Abhijit Guha, Jeremy A. Squire, Xiaoli Wu, Nelson Lau, Nelson Lau, Hao Ding, Astrocyte-specific Expression of Activated p21-ras Results in Malignant Astrocytoma Formation in a Transgenic Mouse Model of Human Gliomas Cancer Research. ,vol. 61, pp. 3826- 3836 ,(2001)
Barbara Majello, Stefano Amente, Miriam Lubrano Lavadera, Giacomo Di Palo, SUMO-activating SAE1 transcription is positively regulated by Myc. American Journal of Cancer Research. ,vol. 2, pp. 330- 334 ,(2012)
Laura Soucek, Manuela Helmer-Citterich, Alessandra Sacco, Richard Jucker, Gianni Cesareni, Sergio Nasi, Design and properties of a Myc derivative that efficiently homodimerizes Oncogene. ,vol. 17, pp. 2463- 2472 ,(1998) , 10.1038/SJ.ONC.1202199
Patrick Shannon, Nesrin Sabha, Nelson Lau, Deepak Kamnasaran, David H. Gutmann, Abhijit Guha, Pathological and Molecular Progression of Astrocytomas in a GFAP:12V-Ha-Ras Mouse Astrocytoma Model American Journal of Pathology. ,vol. 167, pp. 859- 867 ,(2005) , 10.1016/S0002-9440(10)62057-3
G I Evan, M M Mc Gee, D S O'Donovan, S MacFhearraigh, J Whitfield, L B Swigart, Sequential Cdk1 and Plk1 phosphorylation of protein tyrosine phosphatase 1B promotes mitotic cell death. Cell Death and Disease. ,vol. 4, ,(2013) , 10.1038/CDDIS.2012.208
J. D. Kessler, K. T. Kahle, T. Sun, K. L. Meerbrey, M. R. Schlabach, E. M. Schmitt, S. O. Skinner, Q. Xu, M. Z. Li, Z. C. Hartman, M. Rao, P. Yu, R. Dominguez-Vidana, A. C. Liang, N. L. Solimini, R. J. Bernardi, B. Yu, T. Hsu, I. Golding, J. Luo, C. K. Osborne, C. J. Creighton, S. G. Hilsenbeck, R. Schiff, C. A. Shaw, S. J. Elledge, T. F. Westbrook, A SUMOylation-Dependent Transcriptional Subprogram Is Required for Myc-Driven Tumorigenesis Science. ,vol. 335, pp. 348- 353 ,(2012) , 10.1126/SCIENCE.1212728
Laura Soucek, Jonathan Whitfield, Carla P. Martins, Andrew J. Finch, Daniel J. Murphy, Nicole M. Sodir, Anthony N. Karnezis, Lamorna Brown Swigart, Sergio Nasi, Gerard I. Evan, Modelling Myc inhibition as a cancer therapy Nature. ,vol. 455, pp. 679- 683 ,(2008) , 10.1038/NATURE07260
Sheila Alcantara Llaguno, Jian Chen, Chang-Hyuk Kwon, Erica L. Jackson, Yanjiao Li, Dennis K. Burns, Arturo Alvarez-Buylla, Luis F. Parada, Malignant Astrocytomas Originate from Neural Stem/Progenitor Cells in a Somatic Tumor Suppressor Mouse Model Cancer Cell. ,vol. 15, pp. 45- 56 ,(2009) , 10.1016/J.CCR.2008.12.006
Paul Kleihues, Peter C. Burger, Bernd W. Scheithauer, The new WHO classification of brain tumours. Brain Pathology. ,vol. 3, pp. 255- 268 ,(1993) , 10.1111/J.1750-3639.1993.TB00752.X