X-ray crystallographic, FT-IR and NMR studies as well as anticancer and antibacterial activity of the salt formed between ionophore antibiotic Lasalocid acid and amines

摘要: Abstract Two new complexes of the ionophore antibiotic Lasalocid acid (LAS) with phenylamine (PhA) and butylamine (BuA) were synthesized their molecular structures studied using single crystal X-ray diffraction spectroscopic methods. In solid state both amines are protonated all NH 3 + protons hydrogen bonded to etheric, hydroxyl carboxylic oxygen atoms LAS anion. chloroform solutions structure observed in LAS–BuA complex is preserved an equilibrium between LAS–PhA dissociated observed. vitro antimicrobial tests showed a significant activity towards some strains Gram-positive bacteria. For first time its tested for cytotoxic against human cancer cell lines: A-549 (lung), MCF-7 (breast), HT-29 (colon) mouse line P-388 (leukemia). We found that strong agents lines. The cytostatic compounds greater than cisplatin, indicating promising candidates anticancer drugs.