Synthesis, FT-IR, 1H, 13C NMR, ESI MS and PM5 studies of a new Mannich base of polyether antibiotic – Lasalocid acid and its complexes with Li+, Na+ and K+ cations
作者： Adam Huczyński , Jacek Rutkowski , Bogumil Brzezinski , Franz Bartl
DOI: 10.1016/J.SAA.2012.11.106
关键词: Carbon-13 NMR 、 Organic chemistry 、 Decarboxylation 、 Mannich base 、 Medicinal chemistry 、 Derivative (chemistry) 、 Lasalocid 、 Morpholine 、 Chemistry 、 Hydrogen bond 、 Formaldehyde
摘要: Abstract The polyether antibiotic Lasalocid acid has been converted to its Mannich base derivative by a chemoselective one-pot reaction with formaldehyde and morpholine through the decarboxylation process. Spectroscopic studies of structure this new have shown that in ortho -phenol O H⋯N intarmolecular hydrogen bond is present. compound forms complexes Li + , Na K cations exclusively 1:1 stoichiometry. structures these studied visualized semi-empirical calculation based on results spectrometric spectroscopic investigation. It demonstrated contrast novel type preferential cation.
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