Reduced masticatory function is related to lower satellite cell numbers in masseter muscle.

摘要: summary The physiology of masseter muscles is known to change in response functional demands, but the effect on satellite cell (SC) population not known. In this study, hypothesis tested that a decreased demand muscle causes reduction SCs. To end, twelve 5-week-old male Sprague–Dawley rats were put soft diet (SD, n = 6) or hard (HD, and sacrificed after 14 days. Paraffin sections superficial m. digastricus (control muscle) stained with haematoxylin eosin for tissue survey anti-myosin heavy chain (MHC) slow fast fibres. Frozen both double-stained collagen type IV Pax7. Slow MHC fibres equally distributed only localized small area masseter. No differences between HD SD found. had more SCs per fibre than (0.093 ± 0.007 0.081 0.008, respectively; P 0.027). surface an group (758.1 101.6 568.4±85.6, 0.047) (737.7 32.6 592.2 82.2; 0.007). (0.094 0.01 0.008; 0.039). These results suggest reduced function related lower number Reduced might decrease microdamage hence requirement